http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HK-1141511-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
filingDate | 2010-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8558bc8bef16640260547da7ce437dbe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c55fe992e1957ee4ba89444cddb5fbab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c4d4472fdab0bd2b36063aa8047b03e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5093ccb0feba5847945e64dc749931e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5c79ee99565f9ce4e0f3c7c073f9c14 |
publicationDate | 2010-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | HK-1141511-A1 |
titleOfInvention | Process for the resolution of enantiomers and application thereof in the synthesis of ivabradine |
abstract | Process for optical resolution of (3,4-dimethoxy-bicyclo[4.2.0]octa-1 ,3,5-trien-7-yl)nitrile (I) comprises separating enriched racemic or enantiomeric mixture of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien -7-yl)nitrile into its two enantiomers comprising (S)-(3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and (R)-(3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile, by chiral chromatography. Independent claims are included for: (1) (S)-(3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile (Ia); (2) (R)-(3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile (Ib); (3) the synthesis of C-((S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-t rien-7-yl)-methylamine (V) comprising subjecting (Ia) to a reduction reaction; and (4) the synthesis of ivabradine or its salt, and hydrate comprising subjecting (I) to the optic resolution process for obtaining (Ia), transforming (Ia) to (V), transforming (V) to ((S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-ylmethyl)-carbamic acid ethyl ester (VI), reducing (VI) to ((S)-3,4-dimethoxy-bicyclo[4. 2.0]octa-1,3,5-trien-7-ylmethyl)-methyl-amine (III), and transforming (III) to ivabradine or 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1 ,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-te trahydro-2H-3-benzazepin-2-one, which is optionally converted into addition salts with acid comprising hydrochloric, hydrobromic, sulfuric, phosphoric, acetic, trifluoroacetic, lactic, pyruvic, malonic, succinic, glutaric, fumaric, tartaric, maleic, citric, ascorbic, oxalic, methane sulfonic, benzenesulfonic and camphoric or its hydrates. - ACTIVITY : Cardiant; Vasotropic; Antianginal; Antiarrhythmic. - MECHANISM OF ACTION : None given. |
priorityDate | 2008-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.