| abstract |
THE PRESENT INVENTION REFERS TO A SPECIFIC COMBINATION OF A LINKED PRO-DRUG OR A COMPOSITE OF AN ANGIOTENSIN RECEIVER ANTAGONIST AND AN NEPI, IN THE TREATMENT OF HYPERTENSION. THE COMPOUND HAS THE SUM FORMULA [ACID ETHYLESTER ((S) -N-VALERIL-N - {[2'-1H-TETRAZOL-5-IL) -BIFENIL-4-IL] -METIL-} VALINE) (( 2R, 4S) -5-BIFENIL-4-IL-5- (3-CARBOXI-PROPIONILAMINO) -2-METHYL-PENTANOIC] NA3 * X H2O, WHERE X IS FROM 0 TO 3. SUCH COMPOUND FORM A SUPRAMOLECULAR COMPLEX THAT CAN LINK THROUGH NON-COVALENT UNION OR VIA A SODIUM ION. |