| abstract |
THIS INVENTION IS THE ADMINISTRATION OF AN ACAT INHIBITOR TO PREVENT ACCUMULATION OF MONOCITOMACROFAGO AND MMP EXPRESSION IN ARTERIOSCLEROTIC INJURIES. IN ADDITION, THIS INVENTION IS RELATED TO METHODS TO INHIBIT THE DISSTABILIZATION AND / OR RUPTURE OF ARTERIOSCLEROTIC PLATES AND THE TREATMENT OF THE UNSTABLE ANGINA. (See FORMULAS I & II). THE INVENTION PROVIDES METHODS OF TREATMENT OF ARTERIOSCLEROSIS IN A MAMMER, PARTICULARLY A HUMAN, THAT UNDERSTANDS THE ADMINISTRATION OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF A SUFFICIENT ACAT INHIBITOR TO INHIBIT THE ACCUMULATION OF MONOCIRESSION OF THE MATTERIZATION OF THE MATERIALIZATION. IN ADDITION THIS INVENTION IS RELATED TO METHODS OF USE OF COMPOUNDS OF FORMULA I, OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME, WHERE: XEY = OXYGEN, SY CRR '{RR' = H, RENT, OR, HAL, OH, OR BETWEEN BOTH FORM A CYCLE}; R * = H, RENT; R1 & R2 = PHENYLL (REPLACED). |