| abstract |
THE INVENTION REFERS TO AN ELECTRIPAN COMPLEX (A METHYLPIRROLIDINE) AND A BETA CYCLODEXTRINE SULFOBUTILETER [SHOWN IN FIGURE I, WHERE "R" = OH OO (CH2) 4) SO3 H], OR PHARMACEUTICALLY ACCEPTABLE SALES OF MIS PROCEDURES FOR THE PREPARATION OF SUCH COMPLEX, INCLUDING PHARMACEUTICAL FORMULATIONS AND USES OF THE SAME. ELETRIPTAN IS A 5HT RECEIVER AGONIST AND HAS BEEN HIGHLY EFFECTIVE FOR MIGRAINE TREATMENT, EMESIS HYPERTENSION, DEPRESSION, DRUG DEPENDENCY. IN ORDER TO ADMINISTER ELETRIPTAN, OR A SALT OF THE SAME, BY INTRANASAL ROUTE, IT IS DESIRABLE THAT THE FORMULATION DOES NOT PRODUCE IRRITATION IN THE NASAL MUCOSA, WITH THAT PURPOSE THE DEXTRINE COMPLEX HAS BEEN ADDED, ACHIEVING A GOOD BIODISPONIBILITY AND UNDERSTANDING FAST ACTION; THE FORMULATION ALSO INCLUDES INDISPENSABLE COMPONENTS AS ANTIOXIDANTS AND EXCIPIENTS. |