| abstract |
THE PRESENT INVENTION REFERS TO NEW PHARMACOLOGICALLY ACTIVE DERIVATIVES OF TRANSPIPERAZIN1ILESPIRO [CICLOHEXANO1,1'ISOBENZOFURANO] THAT ARE LINKED TO A DOPAMINE RECEPTOR SUBTYPE AND HAVE A PREFERENCE BY THE DOPAM D4 RECEIVER. THESE COMPOUNDS PRESENT CENTRAL DOPAMINERGIC ACTIVITY, AS DEFINED BELOW, AND ARE USEFUL IN THE TREATMENT AND / OR PREVENTION OF DOPAMINE SYSTEM DISORDERS. THESE COMPOUNDS HAVE THE CHEMICAL STRUCTURE (I), IN WHICH A, B, R1, R2, R3, R4, R5 AND R6 ARE FUNCTIONAL GROUPS DESCRIBED IN THE RECORD. |