| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e3f12feb7450af344603eb6a4d50af1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_99a5693fc13a0f4106a3470a73967bd6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a2b6807467efc647a54493bf9a139cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aba8e323d35f5406a3d8c5fb17e82d84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8bdf1bd08e529f06d1c2772c738c8a1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0453
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F13-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K103-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2018-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_283e63d4f4d59c002a429e25f370d920
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f142f04f7c51d634d1fe6b2ddb8ee20d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dd8bc85e087cb5392c362d6c9088cb6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16bec16a83b91da8aff677878c0dcbdb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef7fb420007a7fe92b342fca16a49a45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7c76c45dcb461fcc8aade23749cacfd |
| publicationDate |
2019-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
GR-1009516-B |
| titleOfInvention |
Tricarbonyl-METAL COMPLEXES WITH METAPTOSEOS benzoheterocyclic derivative of the cyclopentadienyl ANIONTOS WITH HIGH PERMEABILITY the BBB FOR APPLICATIONS IN DIAGNOSIS AND TREATMENT OF DISEASES OF CNS |
| abstract |
The present invention relates to complex metal transition compounds, with an emphasis on 99mTc and Re, which exhibit high blood-brain barrier permeability so that they can be used as diagnostic / therapeutic agents for CNS diseases. The compounds are of the general formula wherein the M (CO) 3+ tricarbonyl metal nucleus is complexed with a cyclopentadienyl anion attached to heterocyclic compounds of the benzothiazole, benzimidazole and benzoxazole families. The crossing of the blood-brain barrier for three compounds with M = 99mTc is between 7.04 and 3.99% ID / gr in 2 min. In addition, the compounds bind in vitro to β-amyloid peptide fibrils and to amyloid plaques characterizing Alzheimer's disease, inhibit β-amyloid peptide toxicity in cell cultures, and produce ROS associated with Alzheimer's disease. They therefore have proven potential for application in the preparation of diagnostic / therapeutic preparations for Alzheimer's disease. In addition, the high crossing of the blood-brain barrier makes them candidates for investigation for the preparation of drugs for CNS diseases. |
| priorityDate |
2018-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |