http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GR-1004073-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 |
| filingDate | 2001-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_849c1a746c738ee95be511abde8cb9b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8471d45fa9c1955864c3972769c6a753 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02a02a19757b09826fc9edcc59ae2d0d |
| publicationDate | 2002-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GR-1004073-B |
| titleOfInvention | METHOD OF PREPARATION OF CITALOPRAM |
| abstract | The present invention relates to a process for the preparation of citalopram comprising reacting a compound of formula (I) with a compound of formula (II) in which X is a suitable leaving group and R is -CH2-O-Pg, -CH2 -NPg1Pg2, -CH2-NMePg1, -CO-N (CH3) 2, -CH (OR1) (OR2), -C (OR4) (OR5) (OR6), -COOR3, -CH2-CO-NH2, -CH = CHR7 or -CO-NHR8 where Pg is a protecting group of an alcohol group, Pg1 and Pg2 are protecting groups of an amino group, R1 and R2 are independently selected from alkyl, alkenyl, alkynyl and aryl or aralkyl optionally substituted with alkyl or aralkyl R1 and R2 together form a chain of 2 to 4 carbon atoms, R3, R4, R5, R6 and R7 are independently selected from alkyl, alkenyl, alkynyl and aryl or aralkyl optionally substituted with alkyl and R8 is hydrogen or methyl; forming a compound of formula (III) in which R is as defined above followed by conversion of the R group to a dimethylaminomethyl group and the isolation of citalopram as a base or a pharmaceutically acceptable salt thereof.nn ΰ |
| priorityDate | 2000-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.