http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GR-1000492-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5d86e910e36dff8a9e8508098c2e45e8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-18 |
| filingDate | 1988-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97defeee5e74002383d3c6fb2cd59a66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e335c7a7c0c7f19585523adbd407d0cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8287ddb4a7efffbcd58ca1e929b7d55 |
| publicationDate | 1992-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GR-1000492-B |
| titleOfInvention | CLONING AND TRANSFER OF TRANSFER PRODUCTS B2. |
| abstract | CDNA coding codes are described for TGF-β2 used to construct expressive bodies capable of directing the high-level expression of mature biologically active TGF-β2 into cross-sectional Chinese ovarian ovarian Hamster cells (CHO cells). TGF-β2, produced and secreted by CHO cross-sectional agents, has a specific activity that is estimated to be about half that of the recombinant TGF-β1. The clones were isolated from a cell line of human prostate adenocarcinoma treated with Tamoxifen (PC-3) using oligonucleotide investigators based on the partial sequence of pure amino acid purified TGF-β2, the green 40-bit BSC-Afr cell line. . The cDNA sequences predict that TGF-β2 is synthesized as a polypeptide precursor form from which the mature 112 amino acid TGF-β2 subunit is obtained by proteolytic fragmentation. Proteins encoded by human TGF-β1 and TGF-β2 cDNA show a total confession of 41%. Mature and amino-terminal regions show 71% and 31% confession respectively. Northern spot analysis certified TGF - β2 copies, 4.1 kb, 5.1, and 6.5 kb using mRNA from some different sources. Analysis of multivitaminized RNA from PC-3 cells treated with Tamoxifen has shown that these cells contain larger amounts of TGF-β1 replicas than TGF-β, although they produce more TGF-β2 protein than TGF-β1. This suggests that there is a post-transfer level of regulation for the production of these proteins. ω |
| priorityDate | 1987-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.