http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-991474-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1962-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1965-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-991474-A |
| titleOfInvention | Novel steroid compounds and their preparation |
| abstract | The invention comprises the 20-aroyloxy-pregnan-11-one compounds having the general formula <FORM:0991474/C2/1> in which OR represents an aroyloxy group and R1 is a free or esterified hydroxy group and R2 is a hydrogen atom or a free or ketalized oxygen atom of a keto group and the D 5 and D 3,5 derivatives thereof and processes for the preparation thereof in which a 20b -aroyloxy-pregn - 4 - ene - 3,11 - dione of the general formula <FORM:0991474/C2/2> in enol form is esterified a 3-position by reaction with an acylating agent to form the corresponding 3 - acyloxy - 20b - aroyloxy - pregna-3,5 - dien - 11 - one, the latter is reduced and simultaneously saponified to form the corresponding 20b - aroyloxy - 3b - hydroxy - pregn-5-en-11-one, the latter is re-esterified at 3-position to form the corresponding 3b -acyloxy-20b - aroyloxy - pregn - 5 - ene - 11 - one, the latter is reacted with an oxidizing agent to form the corresponding 3b -acyloxy-20b -aroyloxy - pregn - 5 - ene - 7,11 - dione, the latter is catalytically hydrogenated to form the corresponding 3b -acyloxy-20b -aroyloxy-5a -pregnane-7,11-dione, the latter is subjected to alcoholysis in the 3-position to form the corresponding 20b - aroyloxy - 3 - hydroxy - 5a -pregnane-7,11-dione and the latter is subjected to ketalization to form the corresponding 7-ketal thereof. In the above reaction scheme reduction and saponification may be effected with sodium borohydride and oxidation with chromic ester in carbon tetrachloride. |
| priorityDate | 1961-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.