http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-990365-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 |
| filingDate | 1961-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1965-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-990365-A |
| titleOfInvention | Cyclopenteno derivatives of the androstene, ª‡-androstane and ª‰-androstane series and process for their manufacture |
| abstract | The invention comprises 16,17-cyclopentenosteroids of the general formula <FORM:0990365/C2/1> (in which X represents hydrogen, hydroxy or acyloxy and A and B together with the nucleus D represent an adrostane or androstene residue) and also their preparation by treating a compound of the general formula <FORM:0990365/C2/2> with a basic condensation agent, particularly an alkali metal hydroxide, carbonate or alcoholate, and esterifying any hydroxyl groups as required. The compounds may contain additional substituents in the steroid nucleus, e.g. methyl groups in the 2- and/or 6-position, halogens in the 6- or 9-position, or hydroxy or keto in the 11-position. Specified starting materials include 16b - acetyl - D 5 - iso pregnen - 3b - ol - 20 - one, 16b - acetyl - D 4 - iso pregnene - 3,20 - dione, 16b - acetyl - iso pregnane - 3,20 - dione, 16b -acetyl - iso allopregnane - 3,20 - dione and the diformate and dibenzoate of 16b -hydroxyacetyl-D 5-iso pregnen-3b -ol-20-one. The new compounds exhibit anti-aldosterone activity and diuretic properties and may be formulated for administration orally or parenterally, e.g. as oily suspensions, crystalline suspensions, solutions, capsules, or tablets. The 16b -acetyl and acyloxyacetyl iso-pregnanes used as starting materials are prepared by reacting the corresponding 3-acyloxy-16-carboxylic acid halides with diazomethane, treating the diazoketone obtained with hydrogen halide and subjecting them to acid hydrolysis or reacting them with carboxylic acids. |
| priorityDate | 1960-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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