http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-981192-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5b5a1a6591658a40a21391d0a022559 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-16 |
| filingDate | 1961-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1965-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-981192-A |
| titleOfInvention | Improvements in or relating to 4 hydroxytryptamine esters |
| abstract | The invention comprises compounds of the general formula <FORM:0981192/C2/1> and their acid addition salts in which either each of R1 and R2 represents a C1-4 alkyl group with the proviso that R1 and R2 need not be dissimila or R1 and R2 together represent a tetra-or penta-methylene chain, R3 represents a C1-4-alkyl group, a C2-4 alkenyl group or an aralkyl group containing up to 10 carbon atoms inclusive and R4 represents the radical of an organic carboxylic acid containing up to 10 carbon atoms inclusive or sulphuric acid and the preparation thereof by esterifying an appropriate 4-hydroxytryptamine with an acid anhydride (R4)2O or acid halide R4-halogen or (when R3 represents an alkenyl group) reacting a compound of the general formula <FORM:0981192/C2/2> (wherein R is an organic carboxylic acid residue which is not split off under the reaction conditions) with an appropriate alkenyl halide. 1 - Methyl - 3 - (21 - diethylaminoethyl) - 4 - hydroxyindol is prepared by condensing 3-(21-diethylaminoethyl) - 4 - benzyloxyindole with methyl iodide and hydrogenolysing the 1-methyl - 3 - (21 - diethylaminoethyl) - 4 - benzyloxyindole so formed. Similarly were prepared 1 - methyl - 3 - (21 - piperidinoethyl) - 4 - benzyloxyan -4-hydroxy-indoles. Pharmaceutical compositions comprise the tryptamine esters of the invention together with an inert carrier. The compounds show central sympathetic nerve system stimulant action and some show serotonin antagonistic properties. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8822702-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11518742-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2742162-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11724985-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11746087-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021179091-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11603353-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5717108-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11680044-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8710093-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773063-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0776977-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11746088-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11591353-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11518743-B2 |
| priorityDate | 1960-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.