http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-980417-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e1886853aff6b63bb43c5557498d84c2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-69 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-40 |
| filingDate | 1962-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75f2efe0f1e3670aa84fb17d4fb5a937 |
| publicationDate | 1965-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-980417-A |
| titleOfInvention | 3-(hydroxyheterocyclyl)-alanines and processes for making them |
| abstract | The invention comprises (a) DL-3-(5-hydroxy-4H - pyran - 4 - on - 2 - yl)alanine and its salts with physiologically tolerable acids and bases, and their preparation by heating a di-(C1- 4 alkyl) acetamido - (5 - hydroxy - 4H - pyran - 4 - on - 2 - ylmethyl) malonate with a mineral acid, optionally followed by salt formation, and (b) DL - 3 - (5 - hydroxy - 1H - pyrid - 4 - on - 2 -yl) alanine and its salts with physiologically tolerable acids and bases, and their preparation by protecting the free hydroxyl group in a di-(C1- 4 alkyl) acetamido - (5 - hydroxy - 4H - pyran - 4 - on - 2 - ylmethyl) malonate (e.g. by benzylation), heating the product with aqueous ammonia in a sealed vessel and hydrolysing the resulting pyridone with acid, optionally followed by salt formation. The starting materials are prepared by condensing a di-(C1- 4 alkyl) acetamidomalonate with 5 - hydroxy - 2 - iodomethyl - 4H - pyran - 4-one in the presence of an alkali metal C1- 4 alkoxide. The compounds of the invention may be used in the treatment of disorders attributable to abnormal levels of catecholamines and/or 5-hydroxytryptamine. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4206216-A |
| priorityDate | 1962-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.