http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-980253-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc2f7134efa50484bb359fda73782848 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0094 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 |
| filingDate | 1961-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1965-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-980253-A |
| titleOfInvention | Process for the manufacture of 18-substituted steroids |
| abstract | 980,253. Steroids. CIBA Ltd. July 19, 1961 [July 19, 1960; June 2, 1961; June 14, 1961,] No. 26162/61. Heading C2U. The invention comprises saturated and unsaturated 18-cyano-20-oxo-, 18-aminomethyl- 20-oxo-, or 18-methylene - 20 - oxo - pregnane compounds or alkylene ketals thereof and processes for the preparation thereof by treating an 18-unsubstituted-20-hydroxy-20- cyano compound of the pregnane series with a compound containing positive monovalent iodine, e.g. N - iodoacetamide, N - iodosuccinimide, iodocyan, t-butylhypoiodite and acyl hypoiodite, and, if desired, in the resulting 18-cyano-20-oxo-pregnane compound any ketalized oxo group or esterified hydroxyl group that may be present is hydrolysed or a free oxo group is ketalized, if desired, the 18-cyano group is reduced to an 18-aminomethyl group and, if desired, the 18-aminomethyl group is quaternized and converted to a methylene group by Hoffmann's method. Reaction is preferably effected with the iodine compound between 50-150‹ C. under visible or U.V. irradiation. Reduction may be effected with lithium aluminium hydride. |
| priorityDate | 1960-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.