http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-976065-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8a0e90292f2ba83d7878baca3838b8a2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C04B35-58 |
| filingDate | 1963-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1964-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-976065-A |
| titleOfInvention | Lumiergoline derivatives |
| abstract | The invention comprises compounds of formula <FORM:0976065/C1/1> wherein R is a hydrogen atom or a methyl group and R1 is the group -CH2NHR11 in which R11 is a hydrogen atom or the radical of an aliphatic, cycloaliphatic, aromatic or heterocyclic carboxylic or sulphonic acid having 1 to 10 carbon atoms, optionally substituted by halogen atoms, free or alkylated amino-groups, nitro-, hydroxy, alkyl, alkoxy, phenoxy, thioether, carboxylic or sulphonic groups, and including alkoxycarbonyl and carbamoyl radicals, and their preparation by irradiating lysergamide or 1-methyl lysergamide with ultra-violet light in dilute aqueous organic acid solution to yield lumilysergamide or 1-methylumilysergamide, reducing the products thus obtained to the corresponding amine, and, if desired, reacting this with the chloride or anhydride of the appropriate carboxylic or sulphonic acid. Numerous acids are listed. 1-methylation may be effected before or after irradiation by reaction with a methyl halide in liquid ammonia and in the presence of metallic potassium. The compounds of the invention have oxytocic; antienteraminic, adrenolytic, hypotensive and sedative activity, and may be used in pharmaceutical compositions in combination with a therapeutically acceptable carrier in forms suitable for oral or parenteral administration, for example as tablets, powders, pills, capsules or liquids. |
| priorityDate | 1962-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.