http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-975972-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9f9afcd0369d6402247555a4656c0917 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C291-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C291-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 |
| filingDate | 1960-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1964-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-975972-A |
| titleOfInvention | Diaryl compounds and process for their preparation |
| abstract | The invention comprises compounds of general formula <FORM:0975972/C1/1> where (X) is <FORM:0975972/C1/2> , one of R and R1 is hydrogen, chloro, lower (1-4C) alkyl or lower alkoxy and the other is -OCnH2nA n being 1-4 and A being a di(lower alkyl)amino group or piperidino or morpholino, and Z is a heterocyclic or cycloalkyl group; their N-oxides, acid addition and quaternary ammonium salts; and the processes for preparing them (1) for ethylenes by dehydration by heating with a mineral acid of a corresponding ethanol wherein (X) is replaced by <FORM:0975972/C1/3> , (2) for methobromide salts of ethylenes by heating a corresponding ethanol with methyl bromide and methanol in a pressure bottle, (3) for ethanes by reduction of the corresponding ethylenes, (4) when the starting material is not an N-oxide or salt, optionally forming salts after dehydration or forming N-oxides or salts after reduction and (5) as exemplified, including N-methylation of products in which Z is piperidyl. 1-[p-(b -Diethylaminoethoxy) phenyl]-1-phenyl-2-(4-piperidyl) ethanol is prepared by hydrogenation of the corresponding pyridyl compound; 1-[p-(b -diethylaminoethoxy) phenyl]-1-phenyl-2-(2-pyridyl) ethanol N-oxide is prepared using hydrogen peroxide. Therapeutic compositions comprise a compound of the invention with a pharmaceutically acceptable carrier. Oral (tablets), parenteral and topical (ointments) administration is mentioned. The compounds have anti-inflammatory, antifungal, uterotrophic, cholesterol-depressing and adrenal-regulatory activities. |
| priorityDate | 1959-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.