http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-966696-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9f9afcd0369d6402247555a4656c0917 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C291-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C291-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 |
| filingDate | 1960-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1964-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-966696-A |
| titleOfInvention | Diaryl compounds and process for preparation |
| abstract | The invention comprises compounds of general formula: <FORM:0966696/C1/1> wherein X is <FORM:0966696/C1/2> , one of R and R1 is hydrogen, chloro, lower (1-4) alkyl or lower (1-4 C) alkoxy and the other of R and R1 is a radical of formula -OCnH2nA where n is 1-4 and A is a di(lower alkyl)amino, piperidino or morpholino group, and Z is piperidyl, N-methyl-piperidyl or cycloalkyl; their acid addition salts and N-oxides; and their preparation (1) by reacting a compound of formula: <FORM:0966696/C1/3> with Grignard reagent of formula: <FORM:0966696/C1/4> where Y is a halogen atom and hydrolysing the reaction product, (2) by reacting a compound of formula: <FORM:0966696/C1/5> with a lithium derivative of formula Z-CH2-Li and hydrolysing the reaction product, and (3) as described including preparation of compounds wherein Z is piperidino by hydrogenation of corresponding pyridyl compounds, and the preparation of compounds of formula: <FORM:0966696/C1/6> by reaction of an alkali metal salt of the corresponding phenol with an appropriate substituted aminoalkyl halide, and the preparation of N-oxides using hydrogen peroxide. Ketones of formula: <FORM:0966696/C1/7> may be prepared by reacting an alkali metal salt of the corresponding phenol with an appropriate substituted aminoalkyl halide. Phenols of formula: <FORM:0966696/C1/8> may be prepared by reaction of an appropriate phenolic ketone with a p-R1-benzyl magnesium halide. Ethanols wherein Z is replaced by pyridyl are prepared as 1-[p-(b -diethylaminoethoxy)phenyl]-1-(4-pyridyl)-2-phenyl-ethanol obtained by reaction of benzyl magnesium chloride with p-(b -diethyl-aminoethoxy)phenyl 4-pyridyl ketone prepared from the corresponding phenol using sodium methylate and b -diethylaminoethyl chloride. Therapeutic compositions contain compounds I and their acid addition salts with pharmaceutically acceptable carriers. Oral (tablets), parenteral and topical (ointments) administration is mentioned. The compounds have anti-inflammatory, anti-fungal, cholesterol depressing and adrenal regulatory activities. |
| priorityDate | 1959-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.