http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-963829-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bf5368888323c3ed67b85309d99a669 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1962-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e6858f9a2fe6d075c3bff832aaaa539 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02a1a9ff9b81ce66fe6e75b53b1875ec |
| publicationDate | 1964-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-963829-A |
| titleOfInvention | 17ª‡,21-alkoxy-methylenedioxy pregnenes and pregnadienes and process therefor |
| abstract | The invention comprises steroids of the general formulae: <FORM:0963829/C1/1> <FORM:0963829/C1/2> wherein X represents a methylene, b -hydroxymethylene, or carbonyl group, Y represents hydrogen or fluorine, R represents an alkyl group containing 1 to 3 carbon atoms and R1 represents hydrogen, chlorine or fluorine or a methyl group, and the preparation thereof by reacting the corresponding 17a , 21 - dihydroxy - 20 - keto - steroids with an excess of the required alkyl orthoformate in the presence of an acid catalyst, for example an aromatic sulphonic acid, a Lewis acid such as stannic chloride or antimony pertochloride, or a salt of an organic base with a mineral acid such as pyridine hydrochloride. 2-Methyl-D 4-3, 20-diketo-17a , 21-dihydroxysteroids are prepared by reacting steroids of the first general formula above with diethyl oxalate and sodium methoxide, treating the resulting corresponding 2-enolate with methyl iodide to form the corresponding 2-methyl compound, and removing the grouping protecting the 17-dihydroxy-acetone side chain with a mineral acid in hot methanol. 11b -Acyloxy-17a , 21-dihydroxy-steroids are prepared by treating steroids of the above general formulae wherein X represents hydroxymethylene in the first general formulae with an acylating agent to form the corresponding 11b -acyloxy compounds, and then hydrolysing the 17a , 21-alkoxymethylene group with a mineral acid. 11b , 21-Dihydroxy-D 16-steroids are prepared by dehydrating at the 16, 17-position the above 11b -acyloxy-17a , 21-dihydroxy-steroids with phosphorus oxychloride or thionyl chloride and then hydrolysing the 11b -acyloxy group in the resulting 11b -acyloxy-21-hydroxy-D 16-steroids. 17a -Monoformates of 17a , 21-dihydroxy-steroids are prepared by hydrolysing the 17a , 21-alkoxy-methylenedioxy steroids of the above general formulae with dilute mineral acid or with an organic acid to form a mixture of the 17a -monoformates and 21-monoformates and separating the two formates from one another. Specification 894,168 is referred to. |
| priorityDate | 1961-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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