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filingDate 1961-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1964-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-963594-A
titleOfInvention Method and apparatus for measuring the binding capacity of thyroid hormonal substances
abstract A polyurethane foam for use in a radio-active tracer test (see Division G1) has incorporated therein 0.5 to 160 parts by weight of a strong base anion-exchange resin per 100 parts by weight of polyurethane. The polyurethane is made by mixing a polyester which may be an alkyd or oil-modified alkyd having a molecular weight from 300 to 8,000 (list given) or polyether formed from a glycol having 2 to 10 carbon atoms (list given) with a diisocyanate or a diisothiocyanate, 2, 4 and 2, 6 toluene diisocyanates being preferred, although othe possibilities are listed. Block co-polymers of ethylene oxide and propylene oxide of the formulae: <FORM:0963594/C3/1> may be used where a = 1 to 6, b = 12 to 40, c = 1 to 6, x = 7 to 19 and y = 1 to 3. The alkyds may be modified by any fatty acid or oil and dimers of linolenic or linoleic acid may be used. A list of tertiary amines which may be used as a catalyst is given. Emulsifiers, preferably non-ionic, such as ethylene oxide condensates derived from castor oils, alcohols, organic acids, phenols or hydroxy esters may be used. The ion-exchange resin is incorporated in the polyester or polyether, and a plasticizer such as tris(b -chloroethyl) phosphate or tricresyl phosphate to give the mix the correct consistency for continuous foam producing machines may be added. In a specific example, 500 grams of a polyether glycol having a molecular weight of 3,500 and a hydroxyl number of 65 is added to 300 grams of a strong base quaternary ammonium anion-exchange resin in the form of the chloride salt prepared (by the reaction of tertiary amines with haloalkylated vinyl aromatic hydrocarbon polymers) as in U.S.A. Specification 2,591,573. To the mixture was added 174 grams of an 80:20 mixture of 2, 4 and 2, 6 toluene diisocyanate and 13.5 grams of a 28.6% aqueous solution of triethylenediamine and the mixture was ejected through an orifice into a mold, to form a foam having a density of 2.3 lbs. per cubic foot and an ion exchange resin concentration of 29.5% of the total foam weight. U.S.A. Specification 2,911,338 also is referred to.
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