http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-963509-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C205-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate | 1962-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1964-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-963509-A |
| titleOfInvention | Hydrazino-imidazolyl-propionic acids and their esters |
| abstract | The invention comprises compounds of the general formula: <FORM:0963509/C1/1> and their non-toxic salts, wherein each of R1 and R11 is a hydrogen atom or a C1-5 alkyl radical and R* is a hydrogen atom or a C1- 6 alkanoyl radical, the side chain being attached to one of the two vicinal ring carbons, and their preparation by reacting a hydrochloric or hydrobromic acid solution of histidine or of its a -alkyl homologues with a nitrite salt, reacting the resulting halopropionic acid derivative with hydrazine and, where R11 is other than hydrogen, esterifying, and when R* is other than hydrogen, acylating the resulting hydrazine acid. The process of the invention may be combined with processes for the preparation of histidine or its a -alkyl homologues wherein an a -bromoalkanoyl bromide R1CHBrCOBr is reacted with benzyl alcohol to form the ester R1CHBrCOOCH2C6H5 then with sodium nitrate in the presence of phloroglucinol and dimethyl-formamide to form the nitro ester R1CHNO2.COOCH2C6H5, the ester is reacted with chloromethylimidazole, the nitro group of the nitro-imidazolyl propionic acid benzyl ester is reduced and the benzyl ester saponified. Antihistamine compositions comprise the imidazoline compounds of the invention together with standard pharmaceutical carriers. They may be in the form of tablets for oral administration or in a form suitable for parenteral administration. |
| priorityDate | 1961-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.