http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-953712-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-567 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-567 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-14 |
| filingDate | 1960-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1964-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-953712-A |
| titleOfInvention | Improvements in or relating to steroids |
| abstract | The invention comprises a compound having the general formula: <FORM:0953712/C2/1> wherein R1 and R11 are hydrogen, a lower alkyl radical (1-8 carbon atoms), a monocyclic aromatic radical, a monocyclic aromatic lower alkyl radical, a monocyclic heterocyclic radical or a monocyclic heterocyclic lower alkyl radical or R1 and R11 when taken together are alkylene, W is the carbonyl radical C=O or b -hydroxymethylene radical, X is hydrogen, hydroxy, acyloxy, or fluorine, Y is hydrogen or methyl, Z111 is hydrogen fluorine, chlorine bromine or iodine and the broken lines appearing inside the rings indicate D 1 and D 6-double bonds which may or may not be present provided that when X represents hydrogen or fluorine Z111 does not represent bromine or iodine, and a process for the preparation thereof which comprises treating a suspension or a solution of a steroid having the formula: <FORM:0953712/C2/2> <FORM:0953712/C2/3> <FORM:0953712/C2/4> wherein W, Y and Z111 are as defined above, R111 is hydrogen or the acyl radical of a hydrocarbon carboxylic acid containing 1-12 carbon atoms inclusive and Z11 is hydrogen fluorine or chlorine in a aldehyde or ketone either alone or in a suitable solvent when the aldehyde or ketone is a solid with an acid catalyst, neutralising the acid and recovering the acetal derivative thus produced. As acid catalyst there may be used perchloric acid, p-toluenesulphonic acid or hydrochloric acid.ALSO:Pharmaceutical compositions having antiinflammatory, salt and water regulating, pituitary inhibiting, progestational and anti-anabolic activities and containing compounds of the formula <FORM:0953712/A5-A6/1> wherein R1 and R11 are hydrogen, a lower alkyl (1-8 carbon atoms) radical, a monocyclic aromatic radical, a monocyclic aromatic lower alkyl radical, a monocyclic heterocyclic radical or a monocyclic heterocyclic lower-alkyl radical or R1 and R11 when taken together are alkylene, W is the carbonyl radical or b -hydroxymethylene radical, X is hydrogen, hydroxy, acyloxy or fluorine, Y is hydrogen or methyl, Z111 is hydrogen, fluorine, chlorine or bromine provided that when X represents hydrogen or fluorine Z111 does not represent bromine or iodine, with or without the known antibiotics such as the penicillins, neomycin, tetracyclin, chloramphenicol and novobiocin and/or antifungal agents such as griseofulvin, are administered systemically and/or topically in ointments, creams, lotions, sprays, tablets, suspensions and solutions. |
| priorityDate | 1960-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.