http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-948523-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1961-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1964-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-948523-A |
| titleOfInvention | 2-halogenated steroids of the pregnane series |
| abstract | The invention comprises steroid compounds of the general formula: <FORM:0948523/C2/1> wherein R represents an alkyl radical containing less than 7 carbon atoms, X represents a halogen, and Y represents hydrogen or a halogen atom or a methyl group. The 2a -bromo- and 2a -chloro-6-methyl-4, 6-pregnadiene compounds of the above formula may be prepared by the required 17a -alkanoyloxy- 2-unsubstituted- 4, 6-pregnadiene-compounds with the required cupric halide in a suitable ionic solvent such as methanol, or with a solution of the required free halogen in a suitable solvent mixture such as acetic acid-chloroform. The 2a -bromo- 6-methyl- 4, 6-pregnadiene compounds may also be prepared by treating the required 17a -alkanoyloxy -2- unsubstituted -6- methyl -4- pregnene compounds with bromine. The 2a -iodo -6- methyl- -4, 6-pregnadiene compounds of the above general formula are prepared by reacting the corresponding 2a -bromo compounds with sodium iodide. The 2a -fluoro -6- -methyl compounds of the above general formula are prepared by condensing the required 17a -alkanoyloxy-pregna- -4, 6-diene -3, 20-diones with diethyl oxalate to form the corresponding 2-ethoxalyl-compounds and treating these compounds with perchloryl fluoride in methanol. The 2a -halo -6- unsubstituted and the 2a -, 6-dihalo compounds of the above general formula are prepared by methods similar to those described above for the preparation of the 2a -halo -6- methyl compounds except the method involving treatment of a 17a -(alkanoyloxy) -pregn -4- ene -3, 20-dione with bromine. |
| priorityDate | 1960-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.