http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-945672-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/D04B35-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/D04B35-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 1960-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1964-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-945672-A |
| titleOfInvention | Pyrazole sulphonamide compounds |
| abstract | The invention comprises pyrazole sulphonamides of the formula: <FORM:0945672/C2/1> and alkali-metal salts thereof, wherein X is pyridyl, p-sulphamoylphenyl, p-carboxyphenyl, methyl or hydrogen, Y is methyl or carboxyl and Z is hydrogen or SO2NR1R2, wherein R1 and R2 are hydrogen or C1-5 alkyl or are joined to form a C1-10 alkylene group, X and Z being selected so that the pyrazole contains at least one sulphamoyl or substituted sulphamoyl group. Preferably X is pyridyl, p-sulphamoylphenyl or p-carboxyphenyl, Y is methyl or carboxyl and Z is hydrogen or sulphamoyl. The compounds are made by treating the corresponding 4-unsubstituted pyrazole with chlorosulphonic acid and reacting the resulting sulphonyl chloride with ammonia; or in the cases where X is p-sulphamoylphenyl, Z is hydrogen and Y is methyl or carboxyl, by reacting sulphamoylphenyl hydrazine with acetylacetone or ethyl acetopyruvate, respectively. Pyrazole compounds used as starting materials i.e. 1-(2-pyridyl)-3, 5-dimethylpyrazole and 1-(p-carboxyphenyl)-3 5-dimethylpyrazole are made by treating the appropriate substituted hydrazine with acetylacetone. Pharmaceutical preparations having diuretic activity comprise the above compounds of the invention and an inert pharmaceutical diluent. The preparations suitably take the form of tablets for oral administration or solutions, preferably in an isotonic aqueous medium, for injection. |
| priorityDate | 1959-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.