http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-945504-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 |
| filingDate | 1961-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1964-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-945504-A |
| titleOfInvention | New corticosteroids and their formation |
| abstract | The invention comprises compounds having the formula: <FORM:0945504/C2/1> in which R1 represents a ketone group, a hydroxy group or the group -OX; R2 and R3 which may be the same or different, connote either a hydroxy group or the group -OX, and X signifies an acyl radical which is derived either from an organic carboxylic acid containing from 1-18 carbon atoms or from a mineral acid and processes for the preparation thereof which comprise the steps of reacting a 3b -acyloxy -5a -pregnan -20- one, the acyloxy substituent of which contains from 1-18 carbon atoms with a Grignard reagent so as to form a 3b -acyloxy-20-hydroxy-20-alkoxy-alkyl-5a -pregnane, subjecting this compound to the action of a dehydrating agent to yield a 3b -acyloxy-20-formyl-5a -pregnane and then condensing this product in an alkaline medium with formaldehyde to yield 3b -hydroxy-20-bis-(hydroxymethylene) -5a - pregnane. This compound may be converted to any of the other compounds of the above formula by first protecting the 20-bis-(hydroxymethylene) grouping e.g. by forming a cyclic ketal with an aldehyde or ketone, and thereafter oxidising, esterifying or saponifying as required. Specifications 945,501, 945,502 and 945,503 are referred to. |
| priorityDate | 1960-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.