http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-943603-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_364b3cbf956b10ca710b6407d25b6fd0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C63-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C63-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-06 |
| filingDate | 1960-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1963-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-943603-A |
| titleOfInvention | Dibenzocycloheptane derivatives |
| abstract | The invention comprises compounds of the formula: <FORM:0943603/C2/1> (wherein X is ethylene or vinylene, R1 and R2 are hydrogen or halogen atoms or alkyl groups of at most 4 carbon atoms, Y is a straight or branched, saturated alkylene chain of at most 6 carbon atoms, which may be interrupted by an oxygen atom, and R3 and R4 are alkyl groups of at most 6 carbon atoms or together with the nitrogen atom represent a saturated, mononuclear 5- or 6-membered heterocyclic group which may include a second hetero atom, or R3 is an alkyl group and R4 an alkylene group linked to Y to form therewith, or part thereof, a saturated 5- or 6-membered heterocyclic group, or the grouping -Y-NR3R4 is a tropanyl radical) and acid-addition and quaternary ammonium salts thereof; and their preparation by reacting a compound of the formula: <FORM:0943603/C2/2> with a compound B-Y-NR3R4 (wherein one of A and B is a halogen atom and the other is -O-metal, or A is a halogen and B is a hydroxyl group) in the presence or absence of a solvent; or by heating a compound of the above general formula wherein A is hydroxyl with the compound HO-Y-NR3R4 in the presence of a dehydrating agent. Detailed examples are given. Dibenzo-(a,d)-1, 4-cycloheptadienyl-5-chloride is prepared from the 5-ol and hydrogen chloride or thionyl chloride. 3-Chloro-dibenzo-(a,d)-1, 4-cycloheptadien-5-chloride is prepared similarly. The dibenzocycloheptane derivatives of the invention, which are stated to have antihistaminic and similar actioities, may be made up into pharmaceutical compositions with suitable carriers. Specification 943,604 is referred to. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5410046-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5534626-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0350309-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5231104-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5089505-A |
| priorityDate | 1959-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.