http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-940274-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5528d8d64c9da539b3fa8028a22bede6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-913 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1960-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1963-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-940274-A |
| titleOfInvention | Synthesis of steroids |
| abstract | The invention comprises steroids of the general formula <FORM:0940274/C2/1> wherein the 1,2-position is saturated or double bonded, X is a halogen, Y11 is hydrogen or the acyloxy radical of a hydrocarbon carboxylic acid of less than 10 carbon atoms, Z is hydrogen or a hydroxy radical, and R is an alkyl radical containing less than 8 carbon atoms and the preparation thereof by reacting the corresponding 11a -hydroxy compound with an alkylsulphonyl halide, and the preparation of steroids of the general formula <FORM:0940274/C2/2> wherein the 1,2-position, X and Z have the above significance and Y represents hydrogen or a hydroxy or acyloxy radical, by desulphonating the steroids of the first general formula above with an alkali metal salt of a lower fatty acid and, when required, hydrolysing a product containing a 21-acyloxy group to form a 21-hydroxy group. The 11a -hydroxy reactants for the first process above may be prepared by 11a -hydroxylating the corresponding 11-unsubstituted steroids with micro-organisms of the species Aspergillus, Rhizopus, Neurospora, Pestaloria, Dactylium, Cephalothesium, Absidia, Delacroixia, Tricothecium, Thamnidium, Syncephalastrum or Penicillium and, when required, acylating a 21-hydroxy compound so formed. 6a -Fluoro-D 4-pregnene-15b , 17a , 21-triol-3,20-dione is obtained as a by-product following the 11a -hydroxylation of 6a -fluoro-D 4-pregnene-17a , 21-diol-3,20-dione using Aspergillus nidulans. 6a -Fluoro-11-epihydrocortisone 11,21-diacetate is obtained as a by-product following the treatment of 6a -fluoro-11-epihydrocortisone 21-acetate 11-mesylate with anhydrous sodium acetate in glucial acetic acid. |
| priorityDate | 1959-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.