http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-940035-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b6fc801b5bfe5304ffa40d938db6e09 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-27 |
| filingDate | 1960-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1963-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-940035-A |
| titleOfInvention | New tri- and tetra-substituted alkylenediamines and acid addition salts thereof |
| abstract | The invention comprises tri- and tetrasubstituted alkylenediamines of the general formula <FORM:0940035/C2/1> (wherein R1 represents a hydrogen atom or an alkyl radical having 1-6 carbon atoms, R2 and R3 represent alkyl radicals of at most 6 carbon atoms or, together with the nitrogen atom to which they are bound, form a pyrrolidino, piperidino or morpholino radical, and Z represents an alkylene radical containing at most 6 carbon atoms in a straight or branched chain) and acid addition salts thereof, and their preparation by condensing 2- (b -phenethyl)- aniline or an N-C1-6 alkyl-2-(b -phenethyl)-aniline with a reactive ester of HO-Z-NR2R3, optionally followed by salt formation. The substituted alkylenediames, which have anti-allergic, anti-convulsive, serotonin-antagonistic and anaesthesia-potentiating activity, may also be prepared by (a) condensing a reactive ester of a compound of the general formula <FORM:0940035/C2/2> with HNR2R3, (b) reducing a compound of the general formula <FORM:0940035/C2/3> (wherein R11, R21, R31 and Z1 each correspond to R1, R2, R3 and Z, respectively, except that in at least one of them at least one methylene group bound to a nitrogen atom is replaced by a carbonyl group), (c) reducing a compound of the general formula <FORM:0940035/C2/4> or (d)-when R1 represents a C1-6 alkyl radical-alkylating the corresponding compound in which R1 is a hydrogen atom. N-Methyl-2-(b -phenethyl)-aniline is prepared by methylating N-p-tolylsulphonyl-2- (b -phenethyl)-aniline and hydrolysing the resulting N-methyl-N-p-tolysulphonyl-2-(b -phenethyl)-aniline. N-Ethyl-2-(b -phenethyl)-aniline is prepared similarly. N-n-Propyl-2-(b -phenethyl)-aniline is prepared by (a) treating 2-(b -phenethyl)-aniline with n-propyl bromide in the presence of sodamide, and (b) refluxing a mixture of 2-(b -phenethyl)-aniline, propionaldehyde and ethanol, dissolving the product in a large quantity of ethanol and subjecting it to catalytic hydrogenation. N-n-Butyl-2-(b -phenethyl)-aniline is prepared by treating 2-(b -phenethyl)-aniline with n-butyl bromide in the presence of sodamide. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3974158-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3974156-A |
| priorityDate | 1959-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.