http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-938432-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 |
| filingDate | 1960-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1963-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-938432-A |
| titleOfInvention | Amino-compounds of the oestrane series and a process for their manufacture |
| abstract | The invention comprises 3-amino-17b -hydroxy-D 1,3,5(10)-oestratriene and the corresponding derivatives in which the 17b -hydroxyl group is functionally converted, for example, an aceoxy group, and a process for the preparation of 3-amino-compounds of the oestrane series wherein a p-quinol of the said series of the general formula <FORM:0938432/IV(a)/1> wherein R1 represents hydrogen or an acyl radical and in which the non-aromatic portion of the steroid system can include any substituent which takes no part in the reaction, is reacted with a hydrazine derivative of the formula RNHNH2 in which R represents an organic group such as a phenyl or 2,4-dinitrophenyl group or a group of the formula NH2CO-, and the resulting azodyestuff is reductively split up, for example, by means of dithionite or hydrogen in the presence of a hydrogenation catalyst. The reactant for the above process may be a p-quinol derived from oestradiol or a 17-ester thereof or from oestrone or a 17-protected keto derivative thereof. The process may be illustrated by the following reaction scheme <FORM:0938432/IV(a)/2>ALSO:Azodyestuffs are prepared by reacting a p-quinol of the oestrane series having the general formula <FORM:0938432/IV(a)/1> wherein R1 represents hydrogen or an acyl group and the non-aromatic portion of the steroid system can include non-reactive substituents such as a 17b -hydroxy or -esterified hydroxy group or a 17-keto or -protected keto group, with a hydrazine derivative of the formula RNHNH2 wherein R is an organic group such as a 2,4-dinitrophenyl or phenyl group or a group of the formula NH2CO-. The process is illustrated by the following reaction scheme. <FORM:0938432/IV(a)/2> |
| priorityDate | 1959-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.