http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-937726-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc2f7134efa50484bb359fda73782848 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- |
| filingDate | 1961-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1963-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-937726-A |
| titleOfInvention | New 4-mercapto-pyrazolo[3,4-d]pyrimidines and process for preparing same |
| abstract | The invention comprises a pyrazolo [3,4-d] pyrimidine of the formula: <FORM:0937726/IV(a)/1> or a tautomer thereof, in which R1 represents an alkyl, cycloalkyl or cycloalkyl-alkyl group, R3 represents a hydrogen atom or a lower alkyl group, R4 represents a free mercapto group or a mercapto group substituted by lower alkyl or an aminoalkyl group and R6 represents a lower alkyl or aralkyl group with the proviso that in a 1,6-dialkyl-3-R3-4-R4-pyrazolo [3,4,d] pyrimidine at least one of the alkyl groups in the 1 and 6-positions contain more than 2 carbon atoms, quaternary ammonium compounds thereof, salts thereof, pharmaceutical preparations thereof and a process for the preparation thereof wherein a 1-R1-3-R3-6-R6-4-X-pyrazolo [3,4-d] pyrimidine, in which X represents a halogen atom and R1, R3 and R6 are as defined above, is reacted with thiourea, a metal salt of a hydrogen sulphide or of an alkylmercaptan or aminoalkylmercaptan, and if desired, in the resulting compound with a free mercapto group, the latter is converted into a substituted mercapto group R4 by reaction with a reactive ester of an alkanol or aminoalkanol and, if desired, the resulting tertiary amine is quaternated and/or a resulting free compound converted into a salt thereof or a resulting salt into the free compound or alternatively a 1-R1-3-R3-6-R6-4-hydroxy-pyrazolo [3,4,d] pyrimidine is reacted with phosphorus pentasulphide and if desired, in a resulting compound with a free mercapto group the latter is converted into a substituted mercapto group as above. When R6 represents phenyl it may be mono-, di-, or tri-substituted by chlorine methoxy, methylene-dioxy or trifluoromethyl. 4-Halogeno-pyrazolo[3,4-d]-pyrimidines are obtained by treating a corresponding 4-hydroxy compound with a halogenating agent, e.g. POCl3. Said pharmaceutical compositions, having coronary-dilating activity, are administered enterally, parenterally or locally in the form of tablets or dragees or in liquid form as solutions, suspensions or emulsions. Specifications 937,722, 937,723 and 937,724 are referred to. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7488733-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8044060-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9096603-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004018474-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8642605-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2305262-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9102679-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8741907-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9328120-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8648085-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9067945-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7615558-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8809345-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8088769-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8809348-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8623901-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8822479-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8912201-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8158633-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7737156-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8623879-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9079905-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8431573-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8455502-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2298773-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8039477-B2 |
| priorityDate | 1960-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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