http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-934574-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d037bc74e34c7d73dd883f208aef0518 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-18 |
| filingDate | 1961-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5a716a537afe7f6b8a6bf2d0f7a448a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab346977f93f9a3ccea22cc454cef668 |
| publicationDate | 1963-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-934574-A |
| titleOfInvention | Steroids |
| abstract | The invention comprises steroido-[2,3-d]-triazoles having at ring A the formula <FORM:0934574/IV(a)/1> having an alpha or beta configuration at C5 and wherein R represents a hydrogen atom or an aryl radical, and acid addition salts thereof, and having at ring A the formula <FORM:0934574/IV(a)/2> wherein Y represents an alkyl, aryl or aralkyl radical and NR12 represents a dialkylamine or morpholine residue, and the preparation of steroido-[2,3-d]-triazoles of the first general formula above wherein R represents an aryl radical by reacting 3-ketosteroids having at ring A the formula <FORM:0934574/IV(a)/3> with a dialkylamine or morpholine in an inert organic solvent in the presence of a catalytic amount of a proton donor such as p-toluene sulphonic acid, and reacting the resulting steroid enamines having at ring A the formula <FORM:0934574/IV(a)/4> wherein NR12 has the above significance, with an aryl azide in an inert organic solvent, and the preparation of steroido-[2,3-d]-triazoles of the first general formula above wherein R represents a hydrogen atom by reacting the steroid enamines of the fourth general formula above with an azide of the formula YOCON3, wherein Y represents an alkyl, aryl or aralkyl radical, such as benzyl azidoformate, in an inert organic solvent, and subjecting the resulting steroido-[2,3-d]-triazoles having at ring A the second formula above wherein Y and NR12 have the above significance to reduction, for example, by means of lithium aluminium hydride or hydrogen in the presence of a hydrogenation catalyst, or to hydrolysis, for example, by means of a solution of an alkali metal hydroxide. In the above compounds and processes, the steroids may be of the 5a - and 5b -pregnane, androstane and cholestane series. Benzyl azidoformate is prepared by reacting benzyl chloroformate and sodium azide. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005523254-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7947726-B2 |
| priorityDate | 1961-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.