http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-929277-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b8b744d430e252fa21c14c2b8dee176 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-568 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-568 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 |
| filingDate | 1959-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1963-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-929277-A |
| titleOfInvention | Steroids and their production |
| abstract | <FORM:0929277/IV(a)/1> <FORM:0929277/IV(a)/2> <FORM:0929277/IV(a)/3> <FORM:0929277/IV(a)/4> <FORM:0929277/IV(a)/5> <FORM:0929277/IV(a)/6> <FORM:0929277/IV(a)/7> The invention comprises 10a -methyl-9b -steroids of the general formulae F and G shown in the Figure wherein X has the formula shown in the figure in which R1 represents a hydrogen atom or the methyl group, R2 represents none or one or more double bonds at one or more of the positions 1, 2, 3, 4, 5, 6, 15 and 16, R3 represents a hydrogen atom or a methyl, ethyl, hydroxy, etherified hydroxy or esterified hydroxy group, R4 represents a keto, hydroxy, etherified hydroxy or esterified hydroxy group, R5 represents a hydrogen or a halogen atom, R6 represents a hydrogen or halogen atom or a hydroxy, etherified hydroxy or esterified hydroxy group, R7 p represents a hydrogen or a halogen atom, R8 represents a hydrogen atom or a hydroxy or keto group, R11 represents a hydrogen atom or a hydroxy, etherified hydroxy or esterified hydroxy group, and -N< represents a secondary amine residue (including cyclic amine); the preparation of the steroids of formula F by adding bromine to an enamine of the general formula D shown in the Figure wherein X and -N< have the above significance; and the preparation of the compounds of the formula G by hydrolysing the compounds of the formula F, and by brominating steroids of the general formula C shown in the Figure wherein X has the above significance, with molecular bromine. Before or after the processes referred to above it is possible to introduce a \D1-double bond by dehydrogenation with iodine pentoxide, iodic acid, selenic acid or selenium dioxide, or by biochemical dehydrogenation, or by dehydrohalogenation; to introduce at the 2-position an alkyl, halo, ester, hydroxy or ether substituent by reaction of a 3-ketone with an oxalic ester followed by either alkylation with an alkyl halide to form a 2-alkyl substituent or halogenation to form a 2-halo substituent which may then be converted to a 2-ester group, then hydrolysed to a 2-hydroxy group and finally etherified to a 2-ether group; to introduce a \D6-double bond by allylic halogenation of a \D4-compound followed by dehydrohalogenation; to oxidise a 3-hydroxy group to a 3-keto group; or to esterify a 3-hydroxy group. In the examples the compounds of formulae XII and XIII in the Figure and the corresponding \D4,6. compounds are prepared. Specifications 929,272, 929,276 and 929,278 also are referred to. |
| priorityDate | 1958-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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