http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-929054-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-28 |
| filingDate | 1962-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_213cdb885e8be3837818321334b14b2c |
| publicationDate | 1963-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-929054-A |
| titleOfInvention | Improvements in and relating to heterocyclic compounds and the manufacture thereof |
| abstract | The invention comprises benzenesulphonyl ureas of the formula <FORM:0929054/IV(a)/1> wherein X and X1 are hydrogen, halogen, e.g. Cl, Br or F, or C1-4 alkyl or alkoxy groups, R is hydrogen or a C1-4 alkyl group and R1 is a C1-4 alkyl group and pharmacologically acceptable acid addition salts thereof; and their preparation by (a) reacting a benzenesulphonyl-urethane with a 1-aminopiperidine; (b) reacting a benzenesulphonylisocyanate with a 1-amino-piperidine; (c) reacting a benzenesulphonyl-urea with a 1-amino-piperidine; (d) reacting a benzenesulphonyl-carbamic halide with a 1-aminopiperidine; (e) reacting a benzenesulphonamide or an alkali-metal salt thereof with a piperidino-isocyanate; (f) reacting a benzenesulphonamide or an alkali-metal salt thereof with a piperidino-carbamoyl halide; (g) reacting an O-methyl-piperidino-isourea with a benzenesulphonyl halide and hydrolysing the resulting product; (h) reacting a benzenesulphonyl-cyanamide with a 1-amino-piperidine and hydrolysing the resulting guanidine; (i) reacting an alkali-metal salt of a benzenesulphonamide with a piperidino-isothiocyanate and oxidising the resulting thiourea or (j) reacting a piperidinourethane with an aryl sulphonamide. The products may be converted into their salts with acids such as hydrochloric, hydrobromic sulphuric, phospheric, tartaric, acetic, citric, succinic, maleic, benzoic and salicylic. Starting materials. 1-Amino-4-alkylpiperidines and 1-amino-4,4-dialkylpiperidines are made by treating the appropriate piperidine with nitrous acid and reducing the resulting 1-nitroso-4-alkyl (or 4,4-dialkyl)-piperidine. 4-Methyl-piperidino-isocyanate is prepared from 1-amino-4-methylpiperidine and phosgene. Pharmaceutical preparations, suitable for the treatment of diabetes, comprise the above compounds of the invention in admixture with a pharmaceutical carrier, preferably for oral administration, but also if desired for intravenous administration in a liquid carrier. The preparations may suitably take the form of capsules, tablets, powders, pills, solutions and suspensions. Specification 808,071 is referred to. |
| priorityDate | 1962-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.