http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-923944-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-939 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 1959-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1963-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-923944-A |
| titleOfInvention | Improvements in or relating to steroids and the manufacture thereof |
| abstract | The invention comprises compounds having the formulae <FORM:0923944/IV(a)/1> <FORM:0923944/IV(a)/2> wherein X is hydrogen, fluorine or chlorine and Y is b -hydroxymethylene or carbonyl and a process for the preparation thereof which comprises reacting the corresponding 21-iodo compound with an agent capable of reducing iodine in the 21-position, e.g. sodium thiosulphate. The 21-iodo compounds may be obtained by esterifying the corresponding 21-hydroxy compounds with a sulphonating agent to obtain a 21-sulphonate ester which on treatment with an alkali metal iodide gives the corresponding 21-iodo compound. The D 4 compounds may be bioconverted into the corresponding D 1,4 compounds by means of the microorganism Septomyxa affinis. Illustrative products of the invention are 6a ,16a -dimethyl-11b ,17a - dihydroxy - 1,4 - pregnadiene - 3,20 - dione, 6a ,16a - dimethyl-9a -fluoro-11b ,17a -dihydroxy-1,4-pregnadiene -3,20-dione, 6a ,16a ,11b , 17a -dihydroxy-4-pregnene-3,20- dione, and 6a , 16a - dimethyl - 9a -fluoro-11b ,17a -dihydroxy-4-pregnene-3,20-dione. Specifications 724,094, 761,490, 771,344, 781,712 and 923,943 are referred to.ALSO:Pharmaceutical compositions comprise compounds having the formul <FORM:0923944/VI/1> <FORM:0923944/VI/2> wherein X is hydrogen, chlorine or fluorine and Y is a b -hydroxymethylene or carbonyl group and a pharmaceutical diluent. They may be administered orally as pills, tablets, capsules, syrups and elixirs, as injectable products in liquid form and topically as ointments, creams, sprays and lotions. Antibiotics e.g. the penicillins, neomycin, tetracyclin, chloramphenicol and novobiocin may also be present. Specifications 724,094, 761,490, 771,344, 781,712 and 923,943 are referred to. |
| priorityDate | 1958-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.