http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-919830-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb3edb9a697ebfa78026d99c5a81b3c3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1959-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2e6c536f22f2d0e461c216eb99c5bd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58e652020c18043b9cc18265d457d5a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2550a3518075dba27d5cf64671cd4b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e26c048343e6bb5a2cdbcd2f0a911ce |
| publicationDate | 1963-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-919830-A |
| titleOfInvention | Esters of cortical steroid hormones |
| abstract | The invention comprises esters of 17a -hydroxy- and 17a ,21-dihydroxy-3,20-diketo-4-pregnenes and the corresponding 1,4-pregnadienes with b -(p-alkoxyphenyl)-propionic acids of the general formula <FORM:0919830/IV (b)/1> wherein R represents an alkyl group containing 1 to 12 carbon atoms, and the preparation thereof by reacting the required steroid with the anhydride or the acid chloride of an acid of the above formula in a solvent such as pyridine, benzene, toluene, ether or chloroform at a temperature between 0 DEG C. and the boiling point of the reaction mixture, for a period between half an hour and 72 hours. When an acid anhydride is used as the esterifying agent, the reaction may be carried out in the presence of an acid catalyst such as p-toluenesulphonic acid. Thus the product may be a 17-ester of 17a -hydroxyprogesterone or a 21-ester of 11-desoxycorticosterone, cortisone, hydrocortisone, prednisone or prednisolone. Therapeutic compositions having hormonal activity suitable for injection contain as the active ingredient the esters defined above, e.g. dissolved in sesame or peanut oil. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4001219-A |
| priorityDate | 1959-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.