http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-916558-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e737b999245afb461a9a9e552e8f3a1e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1960-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb9c75dfdcc0f27064b556a0c693e30b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ea1b1f894bcaccf97bf2b47e592a945 |
| publicationDate | 1963-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-916558-A |
| titleOfInvention | Enol ethers of 4-substituted 3-oxo-í~-steroids |
| abstract | The invention comprises steroids having apart from possible additional unsaturated linkages and substituents at the 11-, 16- and 17-positions the formula <FORM:0916558/IV (b)/1> (wherein R is an alkyl or cycloalkyl radical of at most 7 carbon atoms, R1 is methyl or chlorine and R11 is hydrogen or methyl) and their preparation by reacting the corresponding D 4-3-ketones with the appropriate alcohol ROH or with an orthoester thereof in the presence of a catalytic quantity of hydrogen ions. Conveniently a trialkylorthoformate HC(OR)3 is used, in the presence of a catalytic quantity of the corresponding alcohol and an acid catalyst such as sulphuric, toluene-psulphonic, perchloric or hydrochloric acid, in an inert solvent. Alternatively the alcohol ROH may be used alone in the presence of an azeotropic carrier such as iso-octane. In a third method ethyl orthoformate is used and the pre-formed enol ethyl ether is then reacted with the desired alcohol. The process may be applied to steroids of the androstane, pregnane or spirostane series which may additionally contain unsaturated linkages at positions such as 9-11, 16-17, 17-20 and 20-21, hydroxy or acyloxy groups at positions 11, 16, 17, 20 or 21, oxo groups at positions 11, 17 and 20, alkyl groups of up to 4 carbon atoms at positions such as 11, 16, 17 and 21, ethynyl groups and substituted ethynyl groups of up to 4 carbon atoms at position 17, methylene groups at positions such as 11 and 16, halogen atoms at positions such as 11, 16, 17 and 21, isopropylidenedioxy groups at position 16-17 in 20 - oxo - pregnanes and bis-methylenedioxy groups at position 17a ,20:20,21. Detailed examples are provided. In the Provisional Specification R is defined as an alkyl or alicyclic radical of at most 7 carbon atoms, and reference is made to starting materials containing, in addition to the groups and unsaturated linkages detailed above, unsaturated linkages at positions 6-7, 7-8, 11-12 and 15-16, alkyl groups at positions 1, 2 and 7 and halogen atoms at position 9. Specification 888,165 is referred to. |
| priorityDate | 1960-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.