http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-913353-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d037bc74e34c7d73dd883f208aef0518 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1959-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1962-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-913353-A |
| titleOfInvention | Steroids |
| abstract | The invention comprises compounds of the formula: <FORM:0913353/IV (b)/1> and a process for the production of these compounds by converting a 3b -halogeno-pregn-5-en-2-one into the corresponding 20-ethylene glycol ketal, forming the 3b -Grignard compound from the 20-ketal and reacting it with CO2 to form the corresponding 3b -carboxylic acid whilst retaining the ketal formation at the C-20 position and then decomposing this compound to give 20-oxo-pregn-5-en-3b -oic acid, converting the 20-oxo-pregn-5-en-3b -oic acid into the corresponding 3b -diazoacetyl derivative via the 3b -acid chloride, converting the resulting diazoacetyl-pregn-5-en-20-one into the 3b -haloacetyl-pregn-5-en-20-one and converting the last-mentioned compound into 3b -acetyl-pregn-5-en-20-one. Alternatively the diazoacetyl derivative may be converted into 3b - glycol - pregn - 5 - 20 - one with dilute mineral acids, into 3b -acyloxyacetyl-pregn-5-en-20-one with organic acids, into the tosyl ester of 3b -glycolyl-pregn-5-en-20-one by treatment with p-toluene sulphonic acid. Said tosyl ester is converted into the haloketone with alkali metal halide. |
| priorityDate | 1958-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.