http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-911804-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1a6faffc381ea8994c77336c1d3c9a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 |
| filingDate | 1960-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1962-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-911804-A |
| titleOfInvention | 6ª--fluoro-21-methyl-í~-pregnadien-17ª--ol-3,20-dione intermediate therefor and preparation thereof |
| abstract | The invention comprises 6a - and 6b -fluoro21-methyl-D 4,9(11)-pregnadien-17a -ol-3, 20-diones, the preparation of the 6b -compound by reacting a 6b -fluoro-21-methyl-D 4-pregnene-11,17a -diol-3,20-dione 11-alkyl or aryl-sulphonate with an alkaline reagent such as an alkali metal salt of a fatty acid containing up to 4 carbon atoms or an alkali metal halide, and the isomerization of the 6b -compound to the 6a -compound by treating it with a prototropic agent at a temperature between -5 DEG and 10 DEG C. The reaction with the alkaline reagent is preferably conducted in an anhydrous solvent, the sulphonate being of the 11a - or 11b -series. Suitable prototropic agents are water, alcohols and organic and mineral acids. Examples are given. 6b -Fluoro - 21 - methyl-D 4-pregnene-11,17a diol-3,20-dione 11-alkyl or aryl-sulphonates are prepared by reacting 21-methyl-D 5-pregnene - 3b ,17a - diol - 20 - one with N - bromo acetamide and hydrogen fluoride to give 5a -bromo - 6b - fluoro-21-methyl-pregnane-3b ,17a diol-20-one, oxidizing this to the corresponding 3-ketone, heating this with an alkaline reagent to give 6b -fluoro-21-methyl-D 4-pregnen17a -ol-3,20,dione, microbiologically hydroxylating this to give a 6b -fluoro-21-methyl-D 4pregnene-11,17a -diol-3,20-dione and esterifying this with a sulphonyl halide. Examples of these processes are also provided. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2168006-A1 |
| priorityDate | 1960-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.