http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-904994-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30432c021c19453629a3b69ce104640e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 |
| filingDate | 1961-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1962-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-904994-A |
| titleOfInvention | Cyclopentanopolyhydrophenanthrene derivatives and method for producing same |
| abstract | The invention comprises steroids having a carbon skeleton of fewer than 22 carbon atoms and having in any of the 3-, 17- and 21 - positions a 5,6,7,8-tetrahydro-1-methyl-naphthoxyacetoxy group, and the preparation thereof by reacting the required hydroxy substituted steroid with 5,6,7,8 - tetrahydro - 1 - methyl-2-naphthoxyacetic acid or a functional derivative thereof such as the acyl halides, activated esters and anhydrides thereof. Suitable reactants for the above process are testosterone, 19-nor-testosterone, 17a -ethynyl- and 17a -lower alkyl-19-nor-testosterone, prednisolone, 17a -methyl-D 5-androstene-3b ,17b -diol, 2-hydroxymethylene-17a - methyl-androstan-17b -ol-3-one, dehydroepiandrosterone, estradiol, 17a -methyl-estradiol, estrone and the 3-benzyl ether of estradiol. Detailed examples are given, and in one example estradiol 3-benzyl ether 17-(51,61,71,81-tetrahydro - 11 - methyl-21-naphthoxyacetate) is hydrogenated to form estradiol 17-(51,61,71, 81-tetrahydro-11-methyl-21-naphthoxyacetate). Estradiol-3-benzyl ether is prepared by reacting estradiol and benzyl chloride. 5,6,7,8 - Tetrahydro - 1 - methyl-2-naphthoxy acetic acid is prepared by reacting the required naphthol or an alkali metal salt thereof and an a -halogenated acetic acid ester to form the corresponding ester, and hydrolysing the ester. The corresponding acyl halides are prepared by treating the free acid with inorganic acid halides such as thionyl chloride, phosphorus tribromide or phosphorus oxychloride. |
| priorityDate | 1960-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.