http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-903725-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ad66884a6f2a66126d492e56e09be39 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| filingDate | 1958-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1962-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-903725-A |
| titleOfInvention | Phenthiazine derivatives |
| abstract | The invention comprises compounds of the general formula <FORM:0903725/IV (b)/1> (wherein A is a straight or branched alkylene radical of 2 or 3 carbon atoms, and R1 and R2 are identical or different C1-C3 alkyl radicals or together they form with the adjacent nitrogen atom a saturated heterocyclic ring which is unsubstituted or substituted by a methyl group) and certain acid addition salts thereof, and the preparation thereof by (a) reacting 3-cyanophenthiazine or an alkali metal salt thereof with an aminoalkyl halide Hal-A-NR1R2, or with an alkylene dihalide followed by reaction of the resulting product with an amine HNR1R2, or (b) heating a compound of the general formula <FORM:0903725/IV (b)/2> or a salt thereof, in the presence or absence of a solvent, or (c) cyclizing a compound of the general formula <FORM:0903725/IV (b)/3> by heating in the presence of an alkaline condensation medium, in the presence or absence of a solvent and preferably also in the presence of a hydrogen halide elimination catalyst. The products have analgesic, sympathicolytic, centrally suppressing and antihistaminic properties. 3-Cyanophenthiazine is prepared by reacting 3-chlorophenthiazine with cuprous cyanide. 2 - Bromo - 21 - (311 - dimethylaminopropyl) - amino-41-cyanodiphenyl sulphide is prepared by reacting 2-bromothiophenol with 3-nitro-4-chlorobenzonitrile to form 2-bromo-21-nitro-41-cyanodiphenyl sulphide, reducing this to the corresponding 21-amino-compound and condensing this with 1-dimethylamino-3-chloropropane. 3-Cyano-10-(31-chloropropyl)-phenthiazine is formed as an intermediate by condensing 3-cyanophenthiazine with 1-bromo-3-chloropropane. 3-Cyanophenthiazine-10-carboxlic acid pyrrolidinoethyl ester is prepared by reacting 3-cyanophenthiazine with phosgene and the resulting acid chloride with pyrrolidinoethanol. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7981885-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7923445-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2061788-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2061788-A4 |
| priorityDate | 1957-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.