http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-899595-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc2f7134efa50484bb359fda73782848 |
| filingDate | 1959-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_274632a9912d26766825013837eaa6f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a64ee7e694dda493ae0dbac79384c47 |
| publicationDate | 1962-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-899595-A |
| titleOfInvention | Substituted 3:4-dihydro-1:2:4-benzothiadiazine-1:1-dioxides and their preparation |
| abstract | The invention comprises compounds of the general formula <FORM:0899595/IV (b)/1> (wherein R1 represents a phenyl-lower alkyl radical, in which the phenyl group is unsubstituted or carries one or more lower alkyl, lower alkoxy, methylenedioxy or halogen substituents, R2 represents a hydrogen atom or an unsubstituted or halogen-substituted aliphatic (including cycloaliphatic) or araliphatic hydrocarbon radical, R3 represents a halogen atom or a lower alkyl or trifluoromethyl group, and the term "lower" denotes the presence of 1-3 carbon atoms) and their alkali metal salts, pharmaceutical preparations containing these compounds (see Group VI), and the manufacture of the compounds by reacting a compound of the general formula <FORM:0899595/IV (b)/2> or an alkali metal salt thereof with a reactive ester of an araliphatic alcohol R1OH, or by reacting a compound of the general formula <FORM:0899595/IV (b)/3> with an aldehyde R2CHO, and in either case, if desired, converting a resulting alkali metal salt into a free compound or vice versa. 3,4 - Dihydrohydro - 1,2,4 - benzothiadiazine dioxide derivatives of the second general formula above are prepared by reacting a compound of the third general formula above, but in which R1 represents a hydrogen atom, with an aldehyde R2CHO. Specification 899,596 is referred to.ALSO:Pharmaceutical compositions, having diuretic and hypotensive action, comprise a compound of the general formula <FORM:0899595/VI/1> (wherein R1 represents a phenyl-lower alkyl radical, in which the phenyl group is unsubstituted or carries one or more lower alkyl, lower alkoxy, methylenedioxy or halogen substituents, R2 represents a hydrogen atom or an unsubstituted or halogen-substituted aliphatic (including cycloaliphatic) or araliphatic hydrocarbon radical, R3 represents a halogen atom or a lower alkyl or trifluoromethyl group, and the term "lower" denotes the presence of 1-3 carbon atoms), or an alkali metal salt thereof, in admixture or conjunction with a pharmaceutical carrier suitable for enteral or parenteral administration. They may take the form of tablets, dragees, capsules, solutions, suspensions or emulsions, and may be sterilized and/or may contain preserving, stabilizing, wetting or emulsifying agents, salts for varying the osmotic pressure, buffers, or additional therapeutically useful substances such as hypotensive agents (e.g. Rauwolfia or Veratrum alkaloids, semi-synthetic Rauwolfia analogues, or synthetic hypotensive agents such as hydralazine or dihydralazine) or garglionic blockers (e.g. chlorisondamine). Specification 899,596 is referred to. |
| priorityDate | 1959-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.