http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-898346-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14effe3850d2129f863b969dac4f1db8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-20 |
| filingDate | 1958-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1962-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-898346-A |
| titleOfInvention | Improvements in the production of sulfanilamidodiazines |
| abstract | Amino benzene sulphonamido - substituted - pyridazines, -halopyridazines, -pyrimidines and -halopyrimidines are prepared by mixing the corresponding halo diazine having at least one halogen atom on a ring carbon alpha to a nitrogen atom, and sulphanilamide with an alkali metal carbonate and heating the mixture at a fusion temperature above 100 DEG C. with agitation until reaction substantially ceases, the reaction being effected in the presence of an amount of fluidizing agent, as hereinafter defined, which has been added before or during the fusion. The said agent has a boiling point above the fusion temperature and is an aliphatic amide containing 2 or 3 carbon atoms in the acyl radical, e.g. acetamide, dipropylene glycol a 1 : 3- or other butylene glycol, benzamide, a polyalkylene glycol containing at least 4 monomeric groups, e.g. polyglycol 1200, or a C1-6 alkyl ether of diethylene glycol, e.g. the mono- or di-ethyl ether; the agent is used in an amount equal to at least one-eighth the weight of the halodiazine reactant, and sufficient to make the fused mass stirable. The fusion temperature normally does not exceed 160 DEG C. In examples, 3 : 6-dichlor pyridazine is reacted with sulphanilamine in the presence of K2CO3 and various of the above fluidising agents at 133 DEG C.-145 DEG C. yielding 3-sulphanilamido-6-chloro pyridazine whose recovery and purification is described. In comparative experiments the fluidizing agent is replaced by formamide, dimethyl formamide or triethylene glycol, the yields of product thereby being lowered. The method may also be used to prepare 2-sulphonailamido pyrimidine. Reference has been directed by the Comptroller to Specification 730,949. |
| priorityDate | 1957-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.