http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-885760-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1a6faffc381ea8994c77336c1d3c9a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-65 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-00 |
| filingDate | 1960-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-885760-A |
| titleOfInvention | Tetracycline compounds and the preparation thereof |
| abstract | Halogenated tetracyclines are prepared by contacting an acid-stable tetracycline, particularly a 6-deoxy- or 6-deoxy-6-demethyl-tetracycline or a corresponding 4-desdimethylamino compound, or a mineral acid salt thereof, in a reaction-inert solvent, with at least a molar equivalent of a halogenating agent selected from perchloryl fluoride, bromine, chlorine, iodochloride, iodobromide, N-chloro, N-iodo and N-bromo lower alkanoic acid amides, hydrocarbon dicarboxylic acid imides and N-(lower alkanoyl) aniline, pyridinium perbromide and perchloride hydrohalides, lower alkyl hypochlorites, and 3-chloro-, 3-bromo-, 3,5-dichloro-and 3,5-dibromo-5,5-dimethyl-hydantoin. When the tetracycline starting compound contains a 4-dimethylamino substituent, it is preferably reacted with a chlorinating, brominating or iodinating agent in the presence of an acid catalyst. When perchloryl fluoride is used as fluorinating agent it is preferably used in the presence of an alkali metal lower alkoxide or an alkali or alkaline earth metal hydroxide, bicarbonate or carbonate. When an equimolar amount of chlorinating, brominating or iodinating agent is employed the principal product is the corresponding 11a-halotetracycline; the desdimethylamino compounds give with a 2 : 1 molar ratio the 7,11a-dihalo compound and with a 3 : 1 molar ratio the 7,9,11a-trihalo compounds; the dimethyl amino compounds give with two moles of a chlorinating agent the corresponding 7,11a-dichlorotetracycline but with a brominating or iodinating agent the corresponding 7-bromo or 7-iodo tetracycline is obtained. When the starting compound is an 11a-halo tetracycline p treatment with an equimolar amount of halogenating agent gives, when the 11a halogen is bromine or iodine, a 7-monohalo tetracycline and when the 11a-halogen is chlorine or fluorine the product is a 7-halo-11a-chloro- or fluorotetracycline. Reaction of the starting material with perchloryl fluoride gives an 11a-fluorotetracycline. The 11a-halogen may be removed from the final products by conventional procedures, particularly by hydrogenation. Products whose preparation is described include 11a-chloro-, 11a-bromo-, 11-fluoro-, 11a-iodo and 7,11a-dichloro-6-deoxy-6-demethyl tetracycline, 11a-bromo-6-deoxytetracycline hydrobromide, 11a - bromo - 6 - deoxy - 5 - oxytetracycline, 7,9,11a-tribromo-, 7,9-dibromo-11a-fluoro-, 7-bromo-11a-fluoro-, and 7,9-diiodo-11a-fluoro-6-deoxy - 6 - demethyl - 4 - desdimethylamino - tetracycline, 7, 9 - dibromo - 11a - fluoro - 6 - deoxy - 4 - desdimethylaminotetracycline, and 11a-bromo-6-deoxy-tetracycline.ALSO:Pharmaceutical preparations comprise an 11a-halogenated acid-stable tetracycline (see Group IV (b)) and a pharmaceutical carrier. The preparations may be made up as oral suspensions, as tablets or capsules or as solutions suitable for parenteral administration, and may also contain ascorbic acid. |
| priorityDate | 1959-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.