http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-884847-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc2f7134efa50484bb359fda73782848 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-70 |
| filingDate | 1959-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-884847-A |
| titleOfInvention | Mercapto compounds |
| abstract | The invention comprises amino - phenyl - mercapto-pyridines of the formula <FORM:0884847/IV (b)/1> and salts thereof, in which Ph represents a phenyl radical optionally bearing halogen, C1-6 alkyl, C1-6 alkoxy, amino or aminoalkylamino, especially tertiaryaminoalkylamino, substituents and R is an amino or aminoalkylamino group, preferably in the para-position. The compounds are prepared by treating 3-mercapto pyridine suitably in the form of its alkali-metal salt or in the presence of a condensing agent capable of forming a metal salt, with an appropriate halophenyl compound wherein the halogen atom is activated by an ortho or para nitro group such as p-nitro-chloro or p-nitro-bromo-benzene and reducing the resulting nitro compound, e.g. by nascent hydrogen or catalytic hydrogenation. Alternatively the compounds are prepared by reacting a 3-halo-pyridine with an amino-, acetylamino- or nitro-, mercapto-benzene, suitably in the form of a metal salt, or in the presence of a condensing agent forming such a salt and if necessary converting the acetylamino- or nitrosubstituent to an amino group. A free amino group in the product may be converted into an amino-alkylamino group by treating with an aryl-sulphonyl halide, e.g. p-toluenesulphochloride and reacting the resulting sulphonamide with an aminoalkylhalide, e.g. diethylaminoethyl chloride, in the presence of a condensing agent. Preferred products include p-amino-, o-amino, o : p-diamino, o-chloro-p-amino-, o-amino-p-chloro- and o-amino-p-methyl-, 3-phenylmercaptopyridine. The products are used pharmaceutically. Nitrophenylmercapto - pyridines corresponding to the above amino compounds and 3-(o-toluenesulphonylamino - phenylmercapto) - pyridine are obtained as intermediate products in the examples.ALSO:Pharmaceutical compositions having tranquilizing activity comprise compounds of the formula <FORM:0884847/VI/1> or salts thereof wherein Ph indicates a phenylene radical optionally bearing halogen, C1-6 alkyl C1-6 alkoxy, amine or aminoalkylamino, e.g. diethylaminoethylamino, substituents and R is an amino or aminoalkylamino radical (see Group IV (b)), together with a pharmaceutical carrier. The preparations suitably take the form of tablets, dragees, solutions, suspensions or emulsions and in addition to the carrier material may contain other therapeutically valuable substances. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005526857-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6939885-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10364240-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9890148-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8030517-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0100158-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7335653-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8642808-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0100158-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7999109-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9035096-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7227035-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7582661-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7741519-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7420055-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8211896-B2 |
| priorityDate | 1958-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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