http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-882387-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8a0e90292f2ba83d7878baca3838b8a2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1958-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_163e2396e1072fbe894907aeffb32c1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07b28c0c7d747cd9e8daa54c87cc3479 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9506c4efbb17fcc935d04fd275da728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bcfb8297abdf9267cf4e14fee555c37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cabd6a3253d90c110894f5b72521d8d6 |
| publicationDate | 1961-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-882387-A |
| titleOfInvention | 6ª--methyl-17ª--hydroxyprogesterone and esters thereof and process for their preparation |
| abstract | 6a - Methyl - 17a - hydroxy - progesterone is prepared by oxidising 6b -methyl-allopregnane-3b : 5a : 17a -triol-20-one to 6b -methyl-allopregnane-5a : 17a -diol-3 : 20-dione and dehydrating this with a strong alkali. This process may be combined with esterification of 6a -methyl-17a -hydroxy-progesterone by treatment with the chloride and anhydride of an aliphatic or cycloaliphatic carboxylic acid containing at most 9 carbon atoms in the presence of p-toluene-sulphonic acid and treatment of the product with a dilute mineral acid so as selectively to hydrolyse any 3-enol-acylate which may have been formed; and/or with the preparation of the triol starting material by epoxidation of D 5-pregnene-3b : 17a -diol-20-one ethylene glycol ketal to form 5a : 6a -epoxy-allopregnane-3b : 17a -diol-20-one 20-ethylene glycol ketal, treatment of this with a methyl Grignard reagent and subsequent hydrolysis. Any 5b : 6b -epoxide formed in the epoxidation process is removed by crystallisation procedures. Examples illustrate all the above processes, the esters prepared being those of acetic, caproic, oenanthic and cyclopentylpropionic acids. In the Provisional Specification other esterifying acids are also referred to. |
| priorityDate | 1958-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.