http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-881639-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c7d818864ce69f0dc8548437f22a997 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-98 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-98 |
filingDate | 1960-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 1961-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | GB-881639-A |
titleOfInvention | New hydrazinium compounds, their production and pharmaceutical compositions containing them |
abstract | The invention comprises compounds of the formula <FORM:0881639/IV (b)/1> wherein R is a lower alkyl radical and X is an anion bearing the charge n, the piperidine nucleus being substituted by a radical R1 and optionally also by a radical R11, R1 being a hydroxy lower alkyl, alkoxycarbonyl, acyloxy or acyloxy lower alkyl radical, "acyloxy" being defined as phenylcarbamoyloxy, benzoyloxy, mandeloyloxy, diphenylacetoxy, benzilyloxy or fluorene-9-carbonyloxy, and "lower alkyl" referring to alkyl radicals of at most 7 carbon atoms, and R11 being a phenyl radical. They may be prepared by reacting chloramine or hydroxylamine-O-sulphonic acid with the appropriate N-alkyl-piperidine. Anions may be exchanged by metathesis. In Examples (1) 1-methyl-3-hydroxymethyl piperdine and chloramine give 1-amino-1-methyl-3-hydroxymethylpiperidinium chloride (picrate and hexafluorophosphate also prepared); (2) the product of (1) and phenyl isocyanate give 1-methyl-1-amino-3-(N-phenylcarbamoyloxy)-methylpiperidinium chloride (picrate also prepared); (3) the product of (1) and diphenylacetyl chloride give 1-amino-1-methyl - 3 - diphenylacetoxymethylpiperidinium-chloride; (4) 1-ethyl-3-diphenyl-acetoxy piperidine and chloramine give 1-amino-1-ethyl-3-diphenyl-acetoxypiperidinium chloride; (5) and (6) the product of (4) is converted into the corresponding diethylbarbiturate, benzoate and tartrate; (7) fluorene-9-carboxylic acid and thionyl chloride give fluorene-9-carboxylic acid chloride, this with 1-methyl-4-hydroxypiperidine gives 4-(fluorene-9-carbonyloxy)-1-methylpiperidine hydrochloride and this (as the free base) with chloramine gives 1-amino-1-methyl-4-(fluorene-9-carbonyloxy)-piperidinium chloride (picrate and hexafluorophosphate also prepared); (8) 4-carboethoxy-4-phenyl-1-methyl-piperidine and chloramine give 1 - amino - 1 - methyl - 4 - phenyl - 4 - carboethoxy-piperidinium chloride (picrate and hexafluorophosphate also prepared); and (9) and (10) the product of (8) is converted into the corresponding iodide, nitrate, ferrocyanide and ferricyanide and the salts with amphomycin, penicillin and o-acetoxy-benzoic acid. An extensive list of further suitable anions X is also provided. Specifications 858,488, and U.S.A. Specifications 2,678,258 and 2,710,248 are referred to.ALSO:Pharmaceutical compositions comprise a compound of the formula <FORM:0881639/VI/1> (wherein R is a lower alkyl radical and X is an anion bearing the charge n, the piperidine nucleus being substituted by a radical R1 and optionally also by a radical R11, R1 being an hydroxy lower alkyl, alkoxycarbonyl, acyloxy or acyloxy lower alkyl radical, "acyloxy" being defined as phenylcarbamoyloxy, benzoyloxy, mandeloyloxy, diphenylacetoxy, benzilyloxy or fluorene-9-carbonyloxy, and "lower alkyl" referring to alkyl radicals of at most 7 carbon atoms and R11 being a phenyl radical) in admixture with a solid or liquid pharmaceutical carrier. Specific examples of X are those listed in Specification 880,974, and ferrocyanide, ferricyanide and amphomycinate. Specification 858,488 and U.S.A. Specifications 2,678,258 and 2,710,248 also are referred to. |
priorityDate | 1960-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.