http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-880992-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97a285d8ecd0184a7e5d89a1e4e07997 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-234 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-234 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-00 |
| filingDate | 1959-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-880992-A |
| titleOfInvention | Compounds of kanamycin and tetracycline type antibiotic |
| abstract | Compounds of kanamycin and a tetracycline are produced by reacting 1 mol of kanamycin with one to four moles of (a) formaldehyde or a polymer thereof and (b) one to four mols of tetracycline, 5-oxytetracycline, 7-chlorotetracycline, anhydrotetracycline, 7-bromotetracycline, 6-deoxytetracycline or 6-demethyldeoxytetracycline. The compounds are prepared by adding an aqueous solution of kanamycin to a solution of the tetracycline and formaldehyde in a water-miscible organic solvent such as methanol or ethylene glycol monomethyl ether. The kanamycin may be kanamycin A or B, a naturally produced mixture of A and B or a prepared mixture of A and B. The compounds are monoditri- or tetra- N1-tetracyclylmethyl kanamycins wherein, in the case of tetracycline, the N1-tetracyclylmethyl radical has the formula <FORM:0880992/IV (b)/1> a kanamycin molecule being bound to one to four tetracycline molecules through one to four methylene groups, which are attached both to the nitrogen atom of a primary amino group of kanamycin and to the nitrogen atom of the carboxamido group of the tetracycline. The non-toxic acid addition salts may be prepared from these compounds by conventional means. Specification 817,385 is referred to. |
| priorityDate | 1958-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.