http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-880592-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4eacb0405869fef7a8f1c516085f2682 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| filingDate | 1960-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-880592-A |
| titleOfInvention | Improvements in or relating to pyridine carboxylic acid preparation |
| abstract | Pyridine dicarboxylic acids are prepared by contacting quinoline, isoquinoline, and nuclear substituted derivatives thereof, e.g. quinaldine, lepidine, carbostyril, 8-hydroxyquinoline and 2-aminoquinoline, with ozone, in a liquid medium containing a mineral acid, and heating the mixture in the presence of an oxidising agent at a temperature below the boiling point of the mixture. The product is concentrated by distillation, and the acid is filtered and purified. The di-carboxylic acid may be decarboxylated, e.g. by heating, to the mono-acid. The mineral acid which may be nitric, sulphuric, phosphoric, chlorosulphonic, and fluosulphonic is present in an amount of at least one mole of mineral acid per mole of quinoline, and nitric acid which may also be the oxidising agent is preferred. A stabilising agent such as acetic acid may also be present and the ozone may be in air or oxygen. Oxidising agents include nitric acid, hydrogen peroxide, chromic acid, potassium permanganate and perchlorate and the reaction may be batchwise or continuous. Examples describe the preparation of quinolinic acid which may be decarboxylated to nicotinic acid from quinoline, cinchomeronic acid from isoquinoline, and 6-methylquinolinic acid from 2-methylquinoline. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6395903-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4816588-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5122608-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AT-407394-B |
| priorityDate | 1959-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.