http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-880362-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3395c5cb958d81965344886b0ca92581 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 |
filingDate | 1958-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 1961-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | GB-880362-A |
titleOfInvention | Improvements in or relating to steroid compounds |
abstract | The invention comprises 19-nor-cholesterol and esters thereof such as the 3,5-dinitrobenzoate thereof, 19-nor-3-acetoxy-D 3,5-cholestadiene, 19-nor-cholestene-3-one, 19-nor-3-methoxy-D 2,5(10)-cholestadiene, ethers of 19 - nor - 3 hydroxy - D 1,3,5(10)-cholestatriene, and a process for the production of 19-nor-cholesterol by reducing an enol ester of 19-nor-cholesterone, e.g. 19-nor-3-acetoxy-D ,3-5cholestadiene, with an alkali metal borohydride. The above process may be modified in that the 19-nor-cholesterone from which the enol ester is derived is obtained by treating 19-nor-3-hydroxy-D 2,5(10)-cholestadiene ether such as the methyl ether with mineral acid such as hydrochloric acid in methanol, and the latter compound may be prepared by reducing 19-nor-3-hydroxy-D 1,3,5(10)-cholestatriene ether by the Birch method with lithium and ammonia. The 19-nor-cholesterol prepared by the above process may be purified by conversion to the 3,5-dinitro-benzoate thereof and subsequent saponification. The ethers of 19-nor-3-hydroxy-D 1,3,5(10)-cholestatriene may be prepared by etherifying the free 3-hydroxy compound e.g. by means of dimethyl sulphate or diazomethane to form the 3-methyl ether. The enol esters of 19-nor-cholestone may be prepared by reacting 19-nor-cholesterone with a mixture of an acid chloride and an acid anhydride such as acetyl chloride and acetic anhydride. Detailed examples are given. |
priorityDate | 1957-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.