http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-880067-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc2f7134efa50484bb359fda73782848 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-26 |
| filingDate | 1958-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-880067-A |
| titleOfInvention | New aralkyl-piperidines |
| abstract | The invention comprises compounds of the general formula <FORM:0880067/IV (b)/1> in which Ph represents an unsubstituted or halo- or alkyl-substituted phenyl radical and R represents a hydrogen atom, or an unsubstituted or an hydroxy-, halogen- or dialkylaminosubstituted alkyl group, their acid addition and alkyl(C1-5) ammonium salts. The compounds may be prepared (a) by hydrogenation of a compound <FORM:0880067/IV (b)/2> wherein Py is a pyridyl radical; (b) exchanging the group X for hydrogen in compounds of the formula <FORM:0880067/IV (b)/3> wherein X is a group exchangeable for hydrogen and Pi is a piperidyl group, such processes including the dehydration of compounds where X is hydroxyl to give the unsaturated compound followed by hydrogenation of the double bond or reduction of the said hydroxyl group to hydrogen, and decarboxylation of compounds wherein X is carboxyl, preceded if necessary by hydrolysis of a functionally derived carboxylic acid group such as a carbamyl p group; (c) by alkylating secondary aralkylpiperidines by methods known per se including reacting the secondary amino compounds with a 1 : 2-alkylene oxide to form the corresponding tertiary hydroxyalkyl derivatives and (d) by reacting the tertiary hydroxyalkyl compounds with thionyl chloride and the haloalkyl compounds so formed with a dialkylamine. Quaternary ammonium compounds are formed by reacting the tertiary amino compounds with a reactive ester of a C1-5 alkanol, and racemic mixtures are separated by the usual methods into their optically active antipodes. 2-[11-Phenyl-tridecyl-(11)] pyridine is prepared by condensing phenyl-pyridyl-(2)-acetonitrile with lauryl bromide followed by hydrolysis and decarboxylation with sodium or potassium hydroxide. 2-[11-Phenyl-11-hydroxy-tridecyl-(11)] piperidin is prepared by reacting 2-benzoyl-pyridine with lauryl magnesium bromide to give 2-[11-phenyl-11-hydroxy-tridecyl-(11)-pyridine and hydrogenating the pyridine ring. 2-[11-Phenyl-11-carbamyl-tridecyl-(11)] piperidine is prepared by hydrolysis of 2-[11-phenyl-11-cyano-tridecyl-(11)]-pyridine.ALSO:Pharmaceutical and disinfecting compositions comprise compounds of the general formula <FORM:0880067/VI/1> their acid addition salts with organic and inorganic acids or quaternary C1-5-alkyl ammonium compounds, wherein Ph represents an unsubstituted or halo- or alkyl-substituted phenyl radical and R represents a hydrogen atom, an alkyl group or an hydroxy-, halogen-or a dialkylaminoalkyl group, in admixture with an inert carrier. The compositions may be in the form of tablets, dragees, powders, salves, creams, suppositories or in liquid form such as solutions, suspensions or emulsions. If desired they may be sterilized and/or may contain auxiliary substances such as preserving, stabilizing, wetting or emulsifying agents. They may also contain other therapeutically valuable substances. Examples are given of a tablet, a salve, a sprinkling powder, and a solution for disinfecting purposes containing 2-[11-phenyl-tridecyl-(11) ]-N-methyl-piperidine-iodomethylate. |
| priorityDate | 1957-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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