http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-878068-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2922af5d51e7f00664ad528538f92c61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd8844f043fd2755f84624de126f6ae8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| filingDate | 1959-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0277983d08ed0df7a7168319dbb65d7c |
| publicationDate | 1961-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-878068-A |
| titleOfInvention | Improvements in or relating to the preparation of basic benzilic acid ester derivatives |
| abstract | The invention comprises a basic benzilic acid ester derivative of general formula <FORM:0878068/IV (b)/1> in which R is a halogen or hydroxyl group, which may be free, esterified or etherified, or an acid-addition or quaternary ammonium salt of a compound of the above general formula such as the hydrochloride, hydrobromide and methiodide, and processes for the preparation of such a compound (1) by esterifying benzilic acid or a functional derivative (such as the ethyl ester) with 1-dimethylaminopropan-2-ol or with 1-dimethylamino-2-halopropane, (2) by reacting an a ,a -diphenyl-a -acyloxyacetyl halide with 1-dimethylaminopropan-2-ol, (3) by replacing the free hydroxyl group of the benzilic acid ester by a halogen atom by means of thionyl halide, (4) by esterifying the free hydroxyl group of the benzilic acid ester by means of an acid anhydride or chloride, (5) by replacing the halogen atom of the required a ,a -diphenyl-a -haloacetic acid ester by an alkyloxy group, for example by heating with an alcohol or alkali metal alcoholate, and (6) by reacting a ,a -diphenyl-a -alkoxyacetic acid ester with 1-dimethylamino-propanol-(2) and continuously distilling off the alcohol formed. In each of the above processes, the resulting basic benzilic acid ester may be converted into an acid addition or quaternary salt. Detailed examples are given. |
| priorityDate | 1959-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.