http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-876902-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7780e9d205ef3d354fe484bbc65b155c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 1958-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-876902-A |
| titleOfInvention | New cyclopentanophenanthrene derivatives and process for the production thereof |
| abstract | The invention comprises esters of 19-nor-17a -hydroxyprogesterone with hydrocarbon carboxylic acids of from 2 to 12 carbon atoms and a process for their preparation by reacting 19-nor-17a -hydroxyprogesterone with the appropriate acid halide or anhydride in the presence of an acid esterification catalyst, e.g. p-toluene sulphonic acid or perchloric acid, and selectively hydrolysing the resulting enol diacylate to regenerate the D 4-3-keto system. The hydrocarbon carboxylic acids may be saturated or unsaturated, cyclic or aliphatic, and may be substituted, e.g. by halo or methoxy groups. In Examples:-(1) 19-nor-17a -hydroxyprogesterone, acetic anhydride and p-toluene sulphonic acid are heated together, excess anhydride destroyed with water and the precipitated D 3,5-pregnadiene-3b , 17a -diol-20-one diacetate saponified with aqueous methanolic KOH to the acetate of 19-nor-17a -hydroxyprogesterone; (2) as in (1) but using propionic anhydride in the presence of perchloric acid, yielding the propionate of 19-nor-17a -hydroxyprogesterone; other esters similarly prepared are the butyrate, hemi-succinate, caproate, benzoate, cyclopentylpropionate, trimethylacetate, phenoxypropionate and b -chloropropionate. Specification 762,308 is referred to. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3372175-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-3541209-A |
| priorityDate | 1957-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.